MDFIC
Description
The MDFIC (MyoD family inhibitor domain containing) is a protein-coding gene located on chromosome 7.
MDFIC is a protein that contains a MyoD family inhibitor domain. It is required for controlling the activity of various transcription factors through their sequestration in the cytoplasm. MDFIC interacts with multiple proteins, including ZIC1, ZIC2, ZIC3, HIV-1 Tat, Rev, axin, and CCNT2, and plays a role in various cellular processes, including gene regulation, viral replication, and lymphatic vessel development.
MDFIC plays a crucial role in regulating the activity of various transcription factors by sequestering them in the cytoplasm. It specifically retains ZIC1, ZIC2, and ZIC3 proteins in the cytoplasm, preventing their nuclear translocation and transcriptional activation. MDFIC also modulates gene expression from both cellular and viral promoters. It downregulates HIV-1 LTR transcription by interacting with HIV-1 Tat and Rev proteins, interfering with their nuclear import and rendering their nuclear localization signals (NLS) inaccessible to importin-beta. Interestingly, MDFIC also stimulates HTLV-I LTR activation. Additionally, MDFIC binds to the axin complex, leading to an increase in free beta-catenin levels and influencing axin regulation of the Wnt and JNK signaling pathways. MDFIC is involved in the development of lymphatic vessel valves, promoting lymphatic endothelial cell migration by downregulating integrin beta 1 activation and controlling cell adhesion to the extracellular matrix.
MDFIC is also known as HIC, LMPHM12, MDFIC1.
