KDM5D
Description
The KDM5D (lysine demethylase 5D) is a protein-coding gene located on chromosome Y.
KDM5D, encoded by the KDM5D gene, is an enzyme belonging to the alpha-ketoglutarate-dependent hydroxylases superfamily. It contains zinc finger domains. A short peptide derived from KDM5D is a minor histocompatibility antigen that can lead to graft rejection of male donor cells in a female recipient.
KDM5D is a histone demethylase that specifically removes methyl groups from lysine 4 of histone H3 (H3K4), playing a crucial role in regulating gene expression. It acts on trimethylated and dimethylated H3K4, but not monomethylated H3K4. KDM5D does not demethylate other lysine residues on histone H3 (H3K9, H3K27, H3K36, H3K79) or on histone H4 (H4K20). KDM5D may be involved in spermatogenesis and is implicated in transcriptional repression of genes related to metastasis. It is believed to work with ZMYND8 in this process. Additionally, KDM5D suppresses prostate cancer cell invasion and regulates the transcriptional activity of the androgen receptor (AR) by removing H3K4me3 marks, which are associated with active transcription.
KDM5D is also known as HY, HYA, JARID1D, SMCY.
