FLT3LG
Description
The FLT3LG (fms related receptor tyrosine kinase 3 ligand) is a protein-coding gene located on chromosome 19.
Fms-related tyrosine kinase 3 ligand (FLT3LG) is a protein encoded by the FLT3LG gene in humans. It is a hematopoietic four helical bundle cytokine structurally similar to stem cell factor (SCF) and colony stimulating factor 1 (CSF-1). In synergy with other growth factors, Flt3 ligand stimulates the proliferation and differentiation of various blood cell progenitors. It is a major growth factor stimulating the growth of dendritic cells. FLT3L acts as a cytokine and growth factor that increases the number of immune cells (lymphocytes (B cells and T cells)) by activating the hematopoietic progenitors. It binds to and activates FLT3 (CD135) found on multipotent progenitor (MPP) and common lymphoid progenitor (CLP) cells in mice. FLT3L also induces the mobilization of hematopoietic progenitors and stem cells in vivo, potentially aiding in cancer cell killing. FLT3L is crucial for steady-state plasmacytoid dendritic cell (pDC) and classical dendritic cell (cDC) development, and its absence results in low levels of dendritic cells.
FLT3LG is also known as FL, FLG3L, FLT3L.
Associated Diseases
- cancer
- thyroid gland adenocarcinoma
- isolated agammaglobulinemia
- severe combined immunodeficiency due to CARD11 deficiency
- common variable immunodeficiency
- immunodeficiency 18
- severe combined immunodeficiency due to CTPS1 deficiency
- severe combined immunodeficiency due to IKK2 deficiency
- reticular dysgenesis
- agammaglobulinemia 7, autosomal recessive
- combined immunodeficiency due to moesin deficiency
- T-B+ severe combined immunodeficiency due to JAK3 deficiency
- severe combined immunodeficiency due to CORO1A deficiency
- autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity
