ZRSR2
Description
The ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2) is a protein-coding gene located on chromosome X.
ZRSR2 is a human gene encoding an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3‘ splice site in pre-mRNA splicing. This protein may also play a role in network interactions during spliceosome assembly.
ZRSR2 is a pre-mRNA binding protein essential for splicing both U2 and U12 type introns. It specifically interacts with the 3‘ splice site of these pre-mRNAs, contributing to various steps in both U2 and U12 intron splicing. ZRSR2‘s recruitment to U12 pre-mRNAs is ATP-dependent and crucial for prespliceosome assembly, a precursor to other spliceosomal complexes. For U2 type introns, ZRSR2 is specifically required for the second step of splicing.
ZRSR2 is also known as U2AF1-RS2, U2AF1L2, U2AF1RS2, URP, ZC3H22.
Associated Diseases
- myelofibrosis
- lysosomal storage disease
- carcinoma of liver and intrahepatic biliary tract
- acute myeloid leukemia, t(3;5)(q25;q34)
- pancreatic ductal adenocarcinoma
