ZNF609
Description
The ZNF609 (zinc finger protein 609) is a protein-coding gene located on chromosome 15.
ZNF609 acts as a transcription factor that activates the expression of RAG1 and possibly RAG2, playing a role in thymocyte maturation. It cooperates with NIPBL and the Integrator complex to promote cortical neuron migration during brain development by regulating the transcription of specific genes. ZNF609 exhibits a preference for binding to promoters containing paused RNA polymerase II, contributing to the upregulation of genes like SEMA3A, NRP1, PLXND1, and GABBR2, among others.
ZNF609 is also known as -.
Associated Diseases
- Treacher-Collins syndrome
- familial progressive hyperpigmentation
- acroleukopathy, symmetric
- hyperpigmentation with or without hypopigmentation, familial progressive
