ZNF318
The ZNF318 Gene: An Intriguing Player in Human Health and Disease
Description:
The ZNF318 gene resides on chromosome 19 and encodes a zinc-finger protein that plays a fundamental role in gene regulation. It belongs to the Kruppel-like factor (KLF) family, which is known for its involvement in various cellular processes, including cell growth, differentiation, and apoptosis. The ZNF318 protein comprises a characteristic zinc finger domain that enables it to bind specific DNA sequences and modulate gene expression.
Associated Diseases:
Mutations or dysregulation of the ZNF318 gene have been linked to several human diseases:
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Acute Myeloid Leukemia (AML): ZNF318 is one of the most frequently mutated genes in AML, a type of cancer affecting the blood and bone marrow. These mutations disrupt the protein's function, leading to uncontrolled cell growth and proliferation.
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Lymphoma: ZNF318 mutations have also been identified in certain lymphomas, a group of cancers originating in immune cells. The alterations can alter the protein's ability to suppress cell proliferation, contributing to tumor development.
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Neurodevelopmental Disorders: Recent studies suggest that ZNF318 mutations may be associated with neurodevelopmental disorders like autism spectrum disorder (ASD) and intellectual disability. The protein is crucial for proper brain development and function.
Did you Know ?
Approximately 20% of AML patients harbor ZNF318 mutations, highlighting its significant role in leukemia development.
