ZMYND8
Description
The ZMYND8 (zinc finger MYND-type containing 8) is a protein-coding gene located on chromosome 20.
ZMYND8 is a protein encoded by the ZMYND8 gene in humans. It functions as a receptor for activated C-kinase (RACK) protein, binding to activated protein kinase C beta I in vitro. ZMYND8 is also a cutaneous T-cell lymphoma-associated antigen and contains a bromodomain and two zinc fingers, suggesting a role in transcriptional regulation. Multiple transcript variants encoding different isoforms have been identified for this gene.
ZMYND8 acts as a chromatin reader, recognizing specific combinations of histone modifications, including H3.1K36me2-H4K16ac and H3K4me1-H3K14ac. It can act as a transcriptional corepressor for various proteins like KDM5D, KDM5C, and EZH2. ZMYND8 plays a role in DNA damage repair by recruiting the NuRD complex to damaged chromatin, leading to transcriptional repression and homologous recombination repair. Additionally, it activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters. ZMYND8 is involved in the regulation of all-trans-retinoic acid (ATRA)-responsive genes and promotes neuronal differentiation by interacting with the MAPT gene. It also suppresses breast cancer and prostate cancer cell invasion and metastasis.
ZMYND8 is also known as PRKCBP1, PRO2893, RACK7.
