ZMYND12
ZMYND12 Gene: An Intriguing Player in Human Health and Disease
Description
The ZMYND12 (Zinc Finger MYND-type Containing 12) gene, located on chromosome 10q26.3, encodes a protein that plays a crucial role in various cellular processes, including transcriptional regulation, DNA repair, and chromatin remodeling. ZMYND12 is a member of the MYND-type zinc finger protein family, known for their ability to recognize and bind to specific DNA sequences.
Associated Diseases
Mutations in the ZMYND12 gene have been linked to several genetic disorders, including:
- Microcephaly (MCPH): A condition characterized by an unusually small head size at birth.
- Intellectual Disability (ID): A general term for difficulties in intellectual functioning and adaptive behavior.
- Autism Spectrum Disorder (ASD): A developmental disorder that affects social communication and behavior.
- Schizophrenia: A severe mental disorder characterized by hallucinations, delusions, and disorganized thinking.
Did you Know ?
According to a study published in the American Journal of Human Genetics, approximately 1% of individuals with microcephaly have a mutation in the ZMYND12 gene. This highlights the significant role of ZMYND12 in brain development.
