ZFYVE28
Description
The ZFYVE28 (zinc finger FYVE-type containing 28) is a protein-coding gene located on chromosome 4.
ZFYVE28 is a protein encoded by the ZFYVE28 gene in humans.
ZFYVE28 acts as a negative regulator of epidermal growth factor receptor (EGFR) signaling. It promotes EGFR degradation in endosomes when EGFR is not monoubiquitinated.
ZFYVE28 is also known as LST2, LYST2, lst-2.
Associated Diseases
- hemochromatosis type 5
- hereditary hyperferritinemia with congenital cataracts
- cancer
- rapidly progressive glomerulonephritis