ZFPM2
Description
The ZFPM2 (zinc finger protein, FOG family member 2) is a protein-coding gene located on chromosome 8.
ZFPM2 (Zinc finger protein ZFPM2), also known as Friend of GATA2, FOG2, or FOG-2, is a protein encoded by the ZFPM2 gene in humans and the Zfpm2 gene in mice. This widely expressed protein belongs to the FOG family, which regulates transcription factors. It can act as a coactivator or corepressor to modulate the activity of GATA transcription factors. ZFPM2 interacts directly with GATA transcription factors, either enhancing or repressing their ability to stimulate gene expression, depending on the context. ZFPM2 primarily interacts with GATA4 but also interacts with GATA2, GATA5, and GATA6. Its interaction with GATA4 is crucial for the development of various tissues, including the heart, diaphragm, and gonads. Mutations in ZFPM2 can lead to congenital heart defects, congenital diaphragmatic hernias, and ambiguous genitalia in both mice and humans. The ZFPM2 gene is found across various animal species, from flies to humans.
ZFPM2 is also known as DIH3, FOG2, SRXY9, ZC2HC11B, ZNF89B, hFOG-2.
Associated Diseases
- 46,xy sex reversal 9
- Congenital diaphragmatic hernia
- Diaphragmatic hernia 3
- Tetralogy of Fallot
- 46,XY partial gonadal dysgenesis
