ZFP41
The zfp41 Gene: Unraveling Its Role in Human Health
Description
The zfp41 gene, located on chromosome 3q29, encodes a protein called zinc finger protein 41. This protein belongs to the Krüppel-like factor (KLF) family of transcription factors, which play crucial roles in regulating gene expression. ZFP41 contains a unique combination of zinc finger domains, enabling it to bind to specific DNA sequences and modulate the activity of target genes.
Associated Diseases
Mutations in the zfp41 gene have been linked to several human diseases, including:
- Chronic lymphocytic leukemia (CLL): ZFP41 is frequently deleted or mutated in CLL, a type of blood cancer. These alterations disrupt the normal function of ZFP41, leading to uncontrolled cell proliferation and survival.
- Multiple myeloma: ZFP41 expression is often reduced in multiple myeloma, another blood cancer. This downregulation contributes to the growth and progression of myeloma cells.
- Acute myeloid leukemia (AML): ZFP41 mutations have been found in a subset of AML patients. These mutations disrupt ZFP41's tumor suppressor function, promoting leukemia cell growth.
- Other diseases: ZFP41 mutations have also been associated with myelodysplastic syndromes, erythroleukemia, and multiple sclerosis risk.
Did you Know ?
- Approximately 20% of CLL patients harbor mutations in the zfp41 gene. This high frequency of mutations highlights the significant role of ZFP41 in CLL pathogenesis.
