ZFP36L1
Description
The ZFP36L1 (ZFP36 ring finger protein like 1) is a protein-coding gene located on chromosome 14.
Butyrate response factor 1 is a protein that in humans is encoded by the ZFP36L1 gene.
== Function == This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This RNA binding protein most likely functions in regulating the response to growth factors. ZFP36L1 can degrade transcripts of numerous components of senescence-associated secretory phenotype (SASP) factors.
== Interactions == ZFP36L1 has been shown to interact with MAPK14.
ZFP36L1, also known as Butyrate response factor 1, EGF-response factor 1, TPA-induced sequence 11b, Zinc finger protein 36, C3H1 type-like 1, is a zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, thus reducing protein synthesis. It acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein, relaying signaling events to the mRNA decay machinery. ZFP36L1 recruits the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to bound ARE-containing mRNAs, facilitating ARE-mediated mRNA deadenylation and decay processes. It can degrade ARE-containing mRNAs even in the absence of a poly(A) tail. ZFP36L1 binds to the 3'-UTR ARE of numerous mRNAs. It positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). ZFP36L1 promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress. It negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA. ZFP36L1 positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA. It promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, attenuating ESC self-renewal and positively regulating mesendoderm differentiation. ZFP36L1 may play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA. In association with ZFP36L2, it maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation. Together with ZFP36L2, it is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. ZFP36L1 participates in the delivery of target ARE-mRNAs to processing bodies (PBs). In addition to its cytosolic mRNA-decay function, ZFP36L1 plays a role in the regulation of nuclear mRNA 3'-end processing; it modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells. It is also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion. ZFP36L1 plays a role in vasculogenesis and endocardial development. It plays a role in the regulation of keratinocyte proliferation, differentiation, and apoptosis. ZFP36L1 plays a role in myoblast cell differentiation. It associates with the cytoplasmic CCR4-NOT deadenylase and RNA exosome complexes to trigger ARE-containing mRNA deadenylation and decay processes. ZFP36L1 interacts with CNOT1, CNOT6, CNOT7, DCP1A, DCP2, EXOSC2, XRN1, YWHAB, and YWHAZ.
ZFP36L1 is also known as BRF1, Berg36, ERF-1, ERF1, RNF162B, TIS11B, cMG1.
