ZDHHC6
Description
The ZDHHC6 (zinc finger DHHC-type palmitoyltransferase 6) is a protein-coding gene located on chromosome 10.
ZDHHC6 is an endoplasmic reticulum palmitoyl acyltransferase that mediates the attachment of palmitate (a fatty acid) to various proteins, including AMFR, CALX, ITPR1, and TFRC. Palmitoylation of CALX is essential for its interaction with the ribosome-translocon complex, which is crucial for proper folding of glycosylated proteins. ZDHHC6 also facilitates the palmitoylation of AMFR, promoting its localization to the peripheral endoplasmic reticulum. In collaboration with SELENOK, ZDHHC6 palmitoylates ITPR1 in immune cells, influencing ITPR1 stability and function. Additionally, ZDHHC6 acts as a stearoyltransferase, attaching stearate (another fatty acid) to TFRC. This stearoylation inhibits TFRC-mediated activation of the JNK pathway and mitochondrial fragmentation.
ZDHHC6 is also known as DHHC-6, DHHC6, ZNF376.
