ZDHHC23

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Description

The ZDHHC23 (zinc finger DHHC-type palmitoyltransferase 23) is a protein-coding gene located on chromosome 3.

ZDHHC23 acts as a palmitoyltransferase, attaching palmitate to various proteins, potentially influencing a broad range of cellular activities. It specifically palmitoylates KCNMA1, guiding its localization to the plasma membrane. Furthermore, ZDHHC23 may regulate NOS1 and direct its localization to the synaptic membrane. These interactions are supported by experimental evidence from publications (PubMed:22399288).

ZDHHC23 is also known as DHHC-23, NIDD.

Associated Diseases

• X-linked endothelial corneal dystrophy
• granular corneal dystrophy type I
• macular corneal dystrophy
• Thiel-Behnke corneal dystrophy
• corneal endothelial dystrophy
• Schnyder corneal dystrophy
• granular corneal dystrophy type II
• lattice corneal dystrophy type I
• thrombocythemia 2
• autosomal dominant keratitis
• corneal dystrophy, Fuchs endothelial, 3
• schizophrenia 15
• X-linked corneal dermoid
• familial isolated congenital asplenia
• epithelial basement membrane dystrophy