ZDHHC20

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Description

The ZDHHC20 (zinc finger DHHC-type palmitoyltransferase 20) is a protein-coding gene located on chromosome 13.

ZDHHC20 is a palmitoyltransferase that catalyzes the addition of palmitate to various protein substrates, including EGFR. It specifically palmitoylates cysteine residues in the cytoplasmic C-terminus of EGFR, modulating the duration of EGFR signaling by regulating palmitoylation-dependent EGFR internalization and degradation. ZDHHC20 preferentially utilizes acyl-CoA with C16 fatty acid chains, but can also utilize acyl-CoA with C14 and C18 fatty acid chains.

ZDHHC20 is also known as 4933421L13Rik, DHHC-20, DHHC20.

Associated Diseases

• COVID-19
• amelogenesis imperfecta
• dentin dysplasia type I
• dentinogenesis imperfecta type 3
• dentin dysplasia type II
• amelogenesis imperfecta, type 3A
• hypomaturation-hypoplastic amelogenesis imperfecta with taurodontism
• amelogenesis imperfecta hypomaturation type 2A4
• primary failure of tooth eruption
• hypoparathyroidism, familial isolated, 2
• amelogenesis imperfecta type 3B
• dentinogenesis imperfecta