ZDHHC2

Description

The ZDHHC2 (zinc finger DHHC-type palmitoyltransferase 2) is a protein-coding gene located on chromosome 8.

Zinc finger, also known as ZDHHC2, is a human gene.

ZDHHC2, also known as Palmitoyltransferase ZDHHC2, is an enzyme that adds a fatty acid called palmitate to various proteins. This process, called palmitoylation, helps to regulate the location and function of these proteins within cells. ZDHHC2 can also attach other fatty acids, such as myristate and stearate, to proteins. ZDHHC2 is involved in a wide range of cellular processes, including: * Synaptic plasticity in the nervous system, by palmitoylating proteins involved in signal transduction and protein trafficking. * Cell adhesion, by modifying proteins that are important for cell-cell interactions. * G protein-coupled receptor signaling, by regulating the localization of proteins that help to control these important signaling pathways. ZDHHC2 is known to palmitoylate a number of specific proteins, including: * AKAP5, a protein involved in long-term synaptic potentiation. * DLG4, a scaffolding protein that helps to cluster glutamate receptors at synapses. * RGS7BP, a protein that shuttles G protein-coupled receptor signaling proteins to the plasma membrane. * CD9 and CD151, proteins involved in cell adhesion. * CKAP4, a protein that helps to regulate the localization of the endoplasmic reticulum. * LCK, a kinase involved in T cell signaling. ZDHHC2 can exist as a monomer or a dimer. The monomeric form is more active in catalyzing palmitoylation. ZDHHC2 has been shown to promote the replication of Chikungunya virus (CHIKV) by palmitoylating the viral protein nsp1.

ZDHHC2 is also known as DHHC2, ZNF372.

Associated Diseases

WES Whole Exome Sequencing