ZCWPW1

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Description

The ZCWPW1 (zinc finger CW-type and PWWP domain containing 1) is a protein-coding gene located on chromosome 7.

ZCWPW1 acts as a dual histone methylation reader, specifically recognizing PRDM9-catalyzed histone marks H3K4me3 and H3K36me3. This protein plays a role in facilitating the repair of meiotic double-strand breaks (DSBs) induced by PRDM9. It is essential for male fertility and spermatogenesis, specifically required for meiosis prophase I progression in male germ cells but not in female germ cells.

ZCWPW1 is also known as ZCW1.

Associated Diseases

• partial chromosome Y deletion
• spermatogenic failures 50
• spermatogenic failure 25
• male infertility with teratozoospermia due to single gene mutation
• spermatogenic failure, X-linked, 2
• isochromosomy Yp
• isochromosomy Yq
• spermatogenic failure 63
• spermatogenic failure 73
• spermatogenic failure 74
• spermatogenic failure 48
• spermatogenic failure 61
• spinocerebellar ataxia type 32