ZC3H7B
Description
The ZC3H7B (zinc finger CCCH-type containing 7B) is a protein-coding gene located on chromosome 22.
ZC3H7B (zinc finger CCCH-type containing 7B), also known as RoXaN (Rotavirus 'X'-associated non-structural protein), is a protein encoded by the ZC3H7B gene in humans. It contains tetratricopeptide repeat, leucine-aspartate repeat, and zinc finger domains. RoXaN interacts with the rotavirus non-structural protein NSP3. Rotavirus mRNAs are capped but not polyadenylated, and viral proteins are translated by the cellular translation machinery. This is achieved through the action of the viral Nonstructural Protein NSP3 which specifically binds the 3' consensus sequence of viral mRNAs and interacts with the eukaryotic translation initiation factor eIF4G I. RoXaN is a 110-kDa cellular protein containing three regions involved in protein–protein or nucleic acid–protein interactions. A tetratricopeptide repeat region, a protein–protein interaction domain often found in multiprotein complexes, is present in the amino-terminal region. In the carboxy terminus, at least five zinc finger motifs are observed, suggesting RoXaN's ability to bind other proteins or nucleic acids. Between these two regions, a paxillin leucine-aspartate repeat (LD) motif is involved in protein–protein interactions. RoXaN interacts with NSP3 in vivo and during rotavirus infection. Domains of interaction correspond to the dimerization domain of NSP3 (amino acids 163 to 237) and the LD domain of RoXaN (amino acids 244 to 341).
ZC3H7B may play a role in regulating microRNA biogenesis. It binds to microRNAs MIR7-1, MIR16-2 and MIR29A, recognizing the 'ATA(A/T)' motif in the apical loop of these microRNA hairpins.
ZC3H7B is also known as ROXAN1, RoXaN.
