ZC3H12B
Description
The ZC3H12B (zinc finger CCCH-type containing 12B) is a protein-coding gene located on chromosome X.
ZC3H12B, also known as CXorf32 or MCPIP2, is a protein encoded by the ZC3H12B gene located on chromosome Xq12 in humans. The gene spans 19,709 base pairs and consists of 5 exons. It is situated on the X chromosome at q12 on the plus strand. ZC3H12B possesses a ribonuclease domain and a CCCH-type zinc finger domain. Ribonucleases (RNases) degrade RNA and participate in RNA maturation. They also serve as a defense against viral RNA. CCCH-type zinc fingers are linked to mRNA destabilization and have been observed to turnover mRNA without removing the PolyA tail. ZC3H12B and its related proteins (ZC3H12A, ZC3H12C, and ZC3H12D) all contain CCCH-type zinc finger domains, which have been associated with cell cycle and growth phase transitions in eukaryotes. Predictions indicate a 601 bp promoter upstream of the ZC3H12B gene with multiple transcription factor binding sites, including nuclear factor of activated T-cells and ribonucleoprotein associated zinc finger protein MOK-2 (also known as ZNF239).
ZC3H12B is also known as CXorf32, MCPIP2.
Associated Diseases
- hemoglobin D disease
- 46,XY complete gonadal dysgenesis
- dominant beta-thalassemia
- hemoglobin E disease
- hemoglobin C-beta-thalassemia syndrome
- hemoglobin H disease
- 46,XX ovotesticular disorder of sex development
- tetragametic chimerism
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- 46,XX testicular disorder of sex development
- testicular agenesis
- beta-thalassemia-X-linked thrombocytopenia syndrome
- gonadoblastoma
- 46,XY sex reversal 3
- Alzheimer disease
