ZC3H11A
Description
The ZC3H11A (zinc finger CCCH-type containing 11A) is a protein-coding gene located on chromosome 1.
ZC3H11A, encoded by the ZC3H11A gene, is a protein that plays a role in exporting mRNAs from the nucleus to the cytoplasm. It is a component of the transcription export (TREX) complex and is considered a stress-induced nuclear protein, maintaining mRNA export during cellular stress. Loss of ZC3H11A function in HeLa cells leads to a disruption in the replication of nuclear replicating viruses but not cytoplasmic replicating viruses.
ZC3H11A is an RNA-binding protein that interacts with purine-rich sequences and is involved in nuclear mRNA export. It is likely that ZC3H11A associates with the TREX complex to mediate mRNA export.
ZC3H11A is also known as ZC3HDC11A.
Associated Diseases
- Griscelli syndrome type 3
- ringed hair disease
- uncombable hair syndrome
- microcephaly-albinism-digital anomalies syndrome
- pili bifurcati
- syndactyly type 4
- hemoglobin E-beta-thalassemia syndrome
- oculocutaneous albinism type 3
- Tietz syndrome
