ZBTB33
Description
The ZBTB33 (zinc finger and BTB domain containing 33) is a protein-coding gene located on chromosome X.
The ZBTB33 gene encodes the Kaiso protein, a transcriptional regulator with dual DNA-binding specificity. It binds to both methylated CGCG and non-methylated TCCTGCNA sequences. Kaiso recruits the N-CoR repressor complex to promote histone deacetylation and repress target genes, potentially including those in the Wnt signaling pathway. It can also activate transcription of certain genes through the recruitment of CTNND2. Kaiso interacts with several proteins, including HDAC3, Nuclear receptor co-repressor 1, and CTNND1. Named by Dr. Juliet Daniel's, the KAISO gene was named after 'calypso' music popular in the Caribbeans, Trinidad & Tobago, e.t.c.
Kaiso is a transcriptional regulator that exhibits dual DNA binding specificity. It binds to methylated CpG dinucleotides within the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3', which is known as the consensus kaiso binding site (KBS). Kaiso recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures at target gene promoters. This may contribute to the repression of target genes involved in the Wnt signaling pathway. Conversely, Kaiso can also activate transcription of a subset of target genes through the recruitment of CTNND2. Additionally, Kaiso represses the expression of MMP7 in collaboration with the transcriptional corepressors CBFA2T3, CBFA2T2, and RUNX1T1.
ZBTB33 is also known as ZNF-kaiso, ZNF348.
