ZBTB17
Description
The ZBTB17 (zinc finger and BTB domain containing 17) is a protein-coding gene located on chromosome 1.
Zinc finger and BTB domain-containing protein 17 is a protein that in humans is encoded by the ZBTB17 gene. ZBTB17 has been shown to interact with TOPBP1, Host cell factor C1 and Myc.
ZBTB17 is a transcription factor with dual functionality, acting as both an activator and repressor, depending on its interacting partners. It regulates cell cycle progression by targeting negative regulators. ZBTB17 plays a pivotal role in early lymphocyte development, preventing apoptosis in lymphoid precursors, enabling their survival in response to IL7 and proper lineage commitment. Studies have shown its binding to the promoters of adenovirus major late protein and cyclin D1, leading to transcriptional activation. ZBTB17 is crucial for early embryonic development during gastrulation. It represses RB1 transcription, a process that can be counteracted by interaction with ZBTB49 isoform 3/ZNF509S1.
ZBTB17 is also known as MIZ-1, ZNF151, ZNF60, pHZ-67.
