ZBED6
Description
The ZBED6 (zinc finger BED-type containing 6) is a protein-coding gene located on chromosome 1.
Zinc finger, BED-type containing 6 is a protein that in humans is encoded by the ZBED6 gene.
ZBED6 is a transcriptional repressor that binds to the DNA sequence 5'-GCTCGC-3'. Its regulatory activity may vary depending on the tissue. ZBED6 regulates the expression of several target genes, including IGF2, PGAP6/TMEM8, ENHO, and PIANP. It acts as a repressor of IGF2, which in turn negatively regulates postnatal growth in muscles and internal organs, particularly in females. ZBED6 also negatively regulates myoblast differentiation and mitochondrial activity through its control of IGF2 expression. It further negatively regulates the cell cycle of myoblasts, potentially by influencing E2F1 and E2F2 transcription factors. However, ZBED6 positively regulates the cell cycle and survival of pancreatic beta cells. It can bind to the CDH2 gene and repress its transcription, which may regulate pancreatic beta cell adhesion and formation of cell-to-cell junctions with neural crest stem cells. ZBED6 might also contribute to embryonic beta cell differentiation, insulin sensitivity, and glucose clearance.
ZBED6 is also known as MGR.
Associated Diseases
- familial atrial fibrillation
- Brugada syndrome
- familial sick sinus syndrome
- sinoatrial node dysfunction and deafness
- long QT syndrome 9
