ZAK
The ZAK Gene: A Gateway to Understanding Cell Homeostasis
Description
The ZAK gene, also known as the AKT1 substrate 1 (AKT1S1) gene, plays a crucial role in regulating cellular processes essential for life. Located on chromosome 8q24.3, this gene encodes a protein known as ZAK. ZAK functions as a lipid kinase, phosphorylating specific lipids on the cell membrane, thus influencing cell signaling, growth, and metabolism.
Associated Diseases
Dysregulation of the ZAK gene has been linked to several diseases and disorders, including:
- Cancer: ZAK overexpression has been found in various cancers, including breast, lung, and ovarian cancers. It promotes cancer cell proliferation, invasion, and metastasis.
- Diabetes: Mutations in the ZAK gene can impair insulin signaling, leading to type 2 diabetes.
- Cardiovascular diseases: ZAK deficiency has been associated with cardiac hypertrophy, a thickening of the heart muscle, and heart failure.
Did you Know ?
According to a large-scale study published in Nature Genetics, a single nucleotide polymorphism (SNP) in the ZAK gene has been associated with an increased risk of developing breast cancer. Women carrying this specific SNP have a 15% higher risk of breast cancer compared to those who do not carry it.
