YPEL3
Description
The YPEL3 (yippee like 3) is a protein-coding gene located on chromosome 16.
Yippee-like 3 (YPEL3) is a human protein encoded by the YPEL3 gene. It is one of five members of the YPEL family, named after its Drosophila melanogaster orthologue. YPEL3 was initially discovered in a gene expression profiling assay of p53 activated MCF7 cells. Studies have shown that induction of YPEL3 can trigger permanent growth arrest or cellular senescence in certain human normal and tumor cell types. YPEL3 has growth inhibitory effects in both normal and tumor cell lines. It was initially named SUAP (small unstable apoptotic protein) due to its role in cellular growth inhibition via apoptosis in myeloid precursor cell lines. Human YPEL3 is located on the short arm of chromosome 16 (p1611.2) and spans 4.62kb. The Drosophila Yippee protein contains a putative zinc finger motif that is highly conserved among the cysteines and histidines. Zinc fingers serve as structural platforms for DNA binding. DNA methylation of a CpG island near the YPEL3 promoter and histone acetylation are potential epigenetic mechanisms contributing to decreased gene expression in human tumors.
YPEL3 is also known as -.
