YIPF1
Description
The YIPF1 (Yip1 domain family member 1) is a protein-coding gene located on chromosome 1.
The Yip1 domain family is a group of proteins involved in regulating secretory traffic in eukaryotes. The family consists of four members in yeast and nine members in humans. Family members have a shared architecture containing five transmembrane domains. Yip1 domain family members are found in all eukaryotes. The budding yeast Saccharomyces cerevisiae has four Yip1 domain family members: Yif1p, Yip1p, Yip4p, and Yip5p. The amino acid sequence of the Yip domain family members divides them into two groups, called α-subunits and β-subunits. The α-subunits – in yeast Yip1p and Yip4p – are more closely related to each other than they are to the β-subunits, Yip5p and Yif1p. In mammals, both groups are expanded, with α-subunits YipF4, YipF5, YipF6, and YipF7; as well as β-subunits Yif1A, Yif1B, YipF1, YipF2, and YipF3. Yip1 domain family members localize to the Golgi apparatus, where they interact with each other to form complexes involved in trafficking cargo within the Golgi, and/or between the endoplasmic reticulum and Golgi. The Yip1 domain family members are widely distributed throughout the body – with the exception of YipF7 found primarily in the skeletal muscle and tongue, while YipF1A is predominantly in the liver.
YIPF1 is thought to play a role in regulating secretory traffic within the Golgi apparatus and between the endoplasmic reticulum (ER) and Golgi. It interacts with other members of the Yip1 family, including YIPF6, which may help to stabilize YIPF1. YIPF1 may also form a complex with YIPF2 and YIPF6.
YIPF1 is also known as DJ167A19.1, FinGER1, YIPFbeta3A, Yip5a.
