XCL1
Description
The XCL1 (X-C motif chemokine ligand 1) is a protein-coding gene located on chromosome 1.
XCL1, also known as Lymphotactin, is a small cytokine belonging to the C chemokine family. It differs from other chemokines in its structure, containing only two cysteines, one at the N-terminus and one downstream. XCL1 undergoes reversible conformational changes, influencing its binding properties. It is highly expressed in the spleen, thymus, small intestine, and peripheral blood leukocytes, with lower levels found in the lung, prostate gland, and ovary. XCL1 secretion increases intracellular calcium in peripheral blood lymphocytes. It is produced by activated thymic and peripheral blood CD8+ T cells, and NK cells release XCL1 early during infections.
XCL1 is also known as ATAC, LPTN, LTN, SCM-1, SCM-1a, SCM1, SCM1A, SCYC1.
Associated Diseases
- low grade glioma
- systemic lupus erythematosus
- severe combined immunodeficiency due to IKK2 deficiency
- autoinflammatory syndrome with immunodeficiency
- complement component C1s deficiency
- autoinflammatory syndrome, familial, Behcet-like 1
- combined immunodeficiency due to partial RAG1 deficiency
- combined immunodeficiency due to CD3gamma deficiency
