WRNIP1
Description
The WRNIP1 (WRN helicase interacting protein 1) is a protein-coding gene located on chromosome 6.
WRNIP1 is an enzyme encoded by the WRNIP1 gene in humans. It belongs to the AAA ATPase family and interacts with the exonuclease domain of the Werner protein, which is involved in Werner's syndrome, a rare genetic disorder associated with premature aging. WRNIP1 shares similarities with replication factor C family proteins and is conserved across species from E. coli to humans. Studies in yeast suggest that WRNIP1 may influence the aging process. Two transcript variants encoding different isoforms have been identified for this gene. WRNIP1 has been shown to interact with the Werner syndrome ATP-dependent helicase.
WRNIP1 acts as a regulator of DNA replication initiation and restart during DNA polymerase delta-mediated synthesis. Its presence reduces the stimulation of DNA polymerase delta activity in the presence of ATP. Additionally, WRNIP1 plays a role in the innate immune system by enhancing the antiviral response. It stabilizes the interaction of the viral sensor RIGI with double-stranded RNA and promotes the attachment of ubiquitin chains to RIGI, ultimately leading to the activation of the antiviral signaling pathway through the mitochondrial adaptor MAVS.
WRNIP1 is also known as CFAP93, FAP93, WHIP, bA420G6.2.
