WNT9A

Description

The WNT9A (Wnt family member 9A) is a protein-coding gene located on chromosome 1.

WNT9A is a gene that encodes the WNT9A protein, a member of the WNT protein family involved in various developmental processes, including cell fate and patterning during embryogenesis. WNT9A is linked to oncogenesis and is expressed in gastric cancer cell lines. The WNT9A protein shares 75% amino acid similarity with chicken Wnt14, which plays a crucial role in synovial joint formation in the chick limb. The WNT9A gene is located close to another WNT family member, WNT3A, on chromosome 1q42.

WNT9A protein acts as a ligand for the frizzled family of seven transmembrane receptors. It participates in the canonical Wnt/beta-catenin signaling pathway. WNT9A is essential for proper timing of IHH expression during embryonic bone development, normal chondrocyte maturation, and bone mineralization. This protein also plays a redundant role in maintaining joint integrity.

WNT9A is also known as WNT14.

Associated Diseases

WES Whole Exome Sequencing