WISP3
WISP3 Gene: An Intriguing Regulator of Human Health and Disease
Description:
The WISp3 gene (also known as WHSC2, or WNT1 inducible signaling pathway protein 3) is responsible for encoding a protein called WISP3. WISP3 is a secreted protein that plays a crucial role in various cellular processes, including cell growth, differentiation, migration, and death. It belongs to the CCN (CYR61, CTGF, NOV) family of proteins, characterized by their shared structural motifs and involvement in extracellular matrix dynamics and cell signaling.
Associated Diseases:
Dysregulation of WISP3 has been implicated in the pathogenesis of several diseases:
- Cancer: WISP3 overexpression is observed in various cancers, including breast, lung, and prostate cancer. It promotes tumor growth, angiogenesis, and metastasis.
- Cardiovascular diseases: Reduced WISP3 expression is associated with aortic stenosis and coronary artery disease, indicating its potential role in maintaining vascular homeostasis.
- Neurodegenerative diseases: WISP3 has neuroprotective effects and can ameliorate symptoms in models of Parkinson's disease and Alzheimer's disease.
- Cataract: Mutations in the WISp3 gene have been identified in individuals with congenital cataract, a condition characterized by the clouding of the eye's lens.
Did you Know ?
Research has shown that the prevalence of WISp3 gene mutations in congenital cataract cases varies significantly across different populations. In a study of Indian patients, WISp3 mutations were the second most common cause of autosomal dominant congenital cataract, accounting for approximately 12% of cases.
