WDR5
Description
The WDR5 (WD repeat domain 5) is a protein-coding gene located on chromosome 9.
WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.
WDR5 plays a crucial role in histone modification, particularly influencing methylation and acetylation. It facilitates the trimethylation of histone H3 at lysine 4 (H3K4me3), a key epigenetic mark for transcriptional activation. WDR5 participates in the MLL1/MLL complex, mediating methylation and dimethylation of H3K4. It also contributes to acetylation of histone H4 within the NSL complex. Furthermore, WDR5 interacts with other proteins like RBBP5 and ASH2L, stimulating the histone methyltransferase activities of various enzymes, including KMT2A, KMT2B, KMT2C, KMT2D, SETD1A, and SETD1B. Additionally, it is suggested that WDR5 may regulate osteoblast differentiation.
WDR5 is also known as BIG-3, BIG3, CFAP89, SWD3.
