WDR36
Description
The WDR36 (WD repeat domain 36) is a protein-coding gene located on chromosome 5.
WD repeat-containing protein 36 is a protein that in humans is encoded by the WDR36 gene. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG).
WDR36 is a component of the small subunit (SSU) processome, a crucial structure in the early stages of eukaryotic ribosome assembly within the nucleolus. This processome acts as the precursor for the small eukaryotic ribosomal subunit. During its formation, WDR36 collaborates with various ribosome biogenesis factors, an RNA chaperone, and ribosomal proteins to ensure proper pre-rRNA folding, modifications, rearrangements, and cleavage. Additionally, WDR36 plays a role in targeting pre-ribosomal RNA for degradation by the RNA exosome. WDR36 is also involved in the nucleolar processing of the 18S rRNA, a key component of the small ribosomal subunit. Furthermore, WDR36 participates in T-cell activation and demonstrates a strong correlation with the expression of interleukin-2 (IL2).
WDR36 is also known as GLC1G, TA-WDRP, TAWDRP, UTP21.
