WDR3
Description
The WDR3 (WD repeat domain 3) is a protein-coding gene located on chromosome 1.
WDR3 is a protein encoded by the WDR3 gene in humans. It resides in the nucleus and contains 10 WD repeats. These repeats are approximately 30- to 40-amino acid domains with conserved residues, often including a tryptophan-aspartate pair at the C-terminal end. WD repeat proteins are known to participate in various cellular processes such as cell cycle progression, signal transduction, apoptosis, and gene regulation.
WDR3 is a component of the small subunit (SSU) processome, the initial precursor of the small eukaryotic ribosomal subunit. This complex forms in the nucleolus, where WDR3 and other ribosome biogenesis factors, an RNA chaperone, and ribosomal proteins interact with nascent pre-rRNA. Together, they orchestrate RNA folding, modifications, rearrangements, and cleavage, as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
WDR3 is also known as DIP2, UTP12.
Associated Diseases
- endometrial cancer
- schizophrenia 15
- schizophrenia
- Phelan-McDermid syndrome
- Potocki-Lupski syndrome
- cancer
