WDFY1
Description
The WDFY1 (WD repeat and FYVE domain containing 1) is a protein-coding gene located on chromosome 2.
WDFY1 plays a crucial role in the activation of TLR3 and TLR4 signaling pathways by facilitating the interaction between TLR3 or TLR4 and TICAM1. This interaction triggers the activation of transcription factors IRF3 and NF-kappa-B, ultimately leading to the production of interferon-beta (IFN-beta) and pro-inflammatory cytokines.
WDFY1 is also known as FENS-1, FENS1, WDF1, ZFYVE17.
Associated Diseases
- Parkinson disease
- Alzheimer disease
- lysosomal storage disease
- multiple sclerosis
- Brugada syndrome
- familial atrial fibrillation
- schizophrenia
- sinoatrial node dysfunction and deafness
- Jervell and Lange-Nielsen syndrome 1
- Jervell and Lange-Nielsen syndrome 2
- catecholaminergic polymorphic ventricular tachycardia
- Brugada syndrome 1
