WBP11
Description
The WBP11 (WW domain binding protein 11) is a protein-coding gene located on chromosome 12.
WBP11, also known as WW domain binding protein 11, Npw38-binding protein (NpwBP), Splicing factor that Interacts with PQBP-1 and PP1 (SIPP1), and SH3 domain binding Protein, 70 kDa (SNP70), is a protein that plays a role in DNA/RNA transcriptional or post-transcriptional events related to cell division. It is found in the nucleus but not the nucleoli of cells in interphase, but it is distributed throughout the cytoplasm in dividing cells. WBP11 relocates from a peri-nuclear to a cytoplasmic distribution, coinciding with the onset of mitosis in cell division. It is a component of the spliceosome, and Wbp11 fragments block pre-mRNA splicing catalysis. WBP11 interacts with other WW domain of proteins such as the nuclear protein Npw38 via two proline-rich regions. It associates with Npw38 (hence the name NpwBP) in the nuclei and with Poly(rG) and G-rich ssDNA. The 70kDa protein has also been found to interact with SH3 (Src homology domain 3) domains. The C-terminal proline-rich sequences of SNP70/NpwBP/Wbp11, which binds to the WW domain of Npw38 also fits with both classic type I and type II SH3 binding sequences, hence the name (SNP70). Wbp11 was found to bind strongly to the tandem SH3 domains of p47phox and to the N-terminal SH3 domain of p47phox, and more weakly to the SH3 domains from c-src and p85α.
WBP11 activates pre-mRNA splicing and may inhibit PP1 phosphatase activity. These activities are supported by experimental evidence in the literature.
WBP11 is also known as BUG13, CFAP90, FAP90, NPWBP, PPP1R165, SIPP1, VCTERL, VCTRL, WBP-11.
