WASL
Description
The WASL (WASP like actin nucleation promoting factor) is a protein-coding gene located on chromosome 7.
WASL is a gene that encodes a protein known as WASL, which is also known as Neural Wiskott-Aldrich syndrome protein. This protein is involved in various cellular processes, including actin polymerization, cell division, and the formation of cellular protrusions.
WASL, also known as Neural Wiskott-Aldrich syndrome protein, plays a critical role in regulating actin polymerization by stimulating the activity of the Arp2/3 complex. This function is essential for various cellular processes, including mitosis, cytokinesis, and the formation of filopodia. WASL also interacts with CDC42, a protein involved in the extension and maintenance of filopodia. In addition to its cytoplasmic functions, WASL also regulates gene transcription in the nucleus by promoting nuclear actin polymerization. It interacts with various proteins, including HSF1/HSTF1, DNMBP, GRB2, and others, suggesting involvement in a wide range of cellular processes. Further research is ongoing to fully understand the diverse functions and interactions of WASL.
WASL is also known as N-WASP, NWASP, WASPB.
