WAC
Description
The WAC (WW domain containing adaptor with coiled-coil) is a protein-coding gene located on chromosome 10.
WAC, a human gene, encodes a protein that functions as an adapter between gene transcription and histone H2B monoubiquitination. It interacts with various proteins involved in gene regulation, cell cycle control, and autophagy. WAC is essential for maintaining the balance between gene expression, cell growth, and stress response.
WAC acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). It interacts with the RNA polymerase II transcriptional machinery through its WW domain and with RNF20-RNF40 through its coiled coil region, connecting and controlling H2BK120ub1 and gene transcription. WAC regulates cell cycle checkpoint activation in response to DNA damage. It is a positive regulator of amino acid starvation-induced autophagy and also acts as a negative regulator of basal autophagy. WAC positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex (composed of TELO2, TTI1, and TTI2) and the RUVBL complex (composed of RUVBL1 and RUVBL2) into the TTT-RUVBL complex. This results in the dimerization of the mTORC1 complex and its subsequent activation. WAC may negatively regulate the ubiquitin proteasome pathway.
WAC is also known as BM-016, DESSH, PRO1741, Wwp4.
Associated Diseases
- Facial dysmorphism-developmental delay-behavioral abnormalities syndrome due to 10p11.21p12.31 microdeletion
- Desanto-Shinawi syndrome
- Facial dysmorphism-developmental delay-behavioral abnormalities syndrome due to WAC point mutation
