VTCN1
Description
The VTCN1 (V-set domain containing T cell activation inhibitor 1) is a protein-coding gene located on chromosome 1.
V-set domain-containing T-cell activation inhibitor 1 is a protein that in humans is encoded by the VTCN1 gene. B7H4 belongs to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. B7-H4 is an immune checkpoint molecule.
VTCN1 negatively regulates T-cell-mediated immune responses by inhibiting T-cell activation, proliferation, cytokine production, and development of cytotoxicity. When expressed on the surface of tumor macrophages, VTCN1 works with regulatory T-cells (Treg) to suppress tumor-associated antigen-specific T-cell immunity. VTCN1 is also involved in promoting epithelial cell transformation.
VTCN1 is also known as B7-H4, B7H4, B7S1, B7X, B7h.5, PRO1291, VCTN1.
Associated Diseases
- urinary bladder carcinoma
- breast cancer
- cancer
- type 1 diabetes mellitus
- X-linked severe congenital neutropenia
- common variable immunodeficiency
- isolated agammaglobulinemia
- autosomal recessive severe congenital neutropenia due to CSF3R deficiency
