VPS26B
Description
The VPS26B (VPS26 retromer complex component B) is a protein-coding gene located on chromosome 11.
Vacuolar protein sorting 26 homolog B (S. pombe) is a protein in humans that is encoded by the VPS26B gene.
VPS26B acts as a component of the retromer cargo-selective complex (CSC). The CSC is the core functional component of retromer or its variants, preventing missorting of transmembrane cargo proteins into the lysosomal degradation pathway. The CSC is recruited to the endosomal membrane by RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC acts as a recruitment hub for other proteins, such as the WASH complex and TBC1D5. VPS26B may be involved in retrograde transport of SORT1 but not of IGF2R. VPS26B acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1.
VPS26B is also known as Pep8b.
