VCPKMT
Description
The VCPKMT (valosin containing protein lysine methyltransferase) is a protein-coding gene located on chromosome 14.
This protein is a N-lysine methyltransferase that specifically trimethylates Lys-315 of VCP/p97. This modification may decrease VCP ATPase activity. (Evidence: PubMed:22948820, PubMed:23349634)
VCPKMT is also known as C14orf138, METTL21D, VCP-KMT.
Associated Diseases
- hyperinsulinism due to INSR deficiency
- glycogen storage disease VI
- type 1 diabetes mellitus
- cancer
- Alzheimer disease
