VAV3
Description
The VAV3 (vav guanine nucleotide exchange factor 3) is a protein-coding gene located on chromosome 1.
VAV3 is a protein encoded by the VAV3 gene. It is a member of the VAV gene family, whose members are GEFs for Rho family GTPases, which activate pathways involved in cytoskeletal rearrangements and transcriptional changes. VAV3 acts as a GEF primarily for RhoG, RhoA, and to a lesser extent, RAC1. It associates strongly with the nucleotide-free states of these GTPases. Different isoforms of VAV3 have been identified due to alternative splicing. VAV3 has been shown to interact with Grb2.
VAV3 acts as a guanine nucleotide exchange factor (GEF) for GTP-binding proteins RhoA, RhoG, and Rac1, primarily activating the nucleotide-free states of these GTPases. VAV3 plays a significant role in angiogenesis, with its recruitment by phosphorylated EPHA2 being critical for EFNA1-induced RAC1 GTPase activation, endothelial cell migration, and assembly. VAV3 potentially contributes to integrin-mediated signaling in various cell types. In osteoclasts, VAV3, along with SYK tyrosine kinase, is required for signaling through integrin alpha-v/beta-1, crucial for proper cytoskeletal organization and function. This pathway involves RAC1 activation but not RHO activation. VAV3 is necessary for proper wound healing, particularly in the formation of phagocytic cups during macrophage phagocytosis of apoptotic neutrophils. VAV3 is responsible for integrin beta-2-mediated macrophage adhesion and contributes to beta-3-mediated adhesion, but it does not affect integrin beta-1-mediated adhesion.
VAV3 is also known as -.
