VAV2

Description

The VAV2 (vav guanine nucleotide exchange factor 2) is a protein-coding gene located on chromosome 9.

VAV2 is a protein encoded by the VAV2 gene. It is the second member of the VAV oncogene family. Unlike VAV1, which is expressed solely in hematopoietic cells, VAV2 transcripts are found in most tissues. VAV2 functions as a GEF for RAC1, particularly in fibroblasts, where it is essential for integrin-dependent (but not growth factor-dependent) activation of RAC1, leading to lamellipodia formation. Mutations in the DH domain (L342R/L343SVav2) act as a dominant negative, blocking VAV2 GEF activity for RAC1. A PH domain mutant is required for VAV2 recruitment to the membrane to initiate GEF activity. VAV2 has also been shown to regulate collagen phagocytosis in a RAC1-dependent manner and interact with CD19 and Grb2.

VAV2 acts as a guanine nucleotide exchange factor (GEF) for the Rho family of Ras-related GTPases. It plays a crucial role in angiogenesis, particularly in the activation of RAC1 GTPase. VAV2 is recruited by phosphorylated EPHA2, which is essential for EFNA1-induced RAC1 activation, vascular endothelial cell migration, and assembly.

VAV2 is also known as VAV-2.

Associated Diseases

WES Whole Exome Sequencing