VASH1

Description

The VASH1 (vasohibin 1) is a protein-coding gene located on chromosome 14.

Vasohibin-1 is a protein that in humans is encoded by the VASH1 gene.

VASH1 encodes a tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, regulating microtubule dynamics and function. This enzyme is essential for spindle function and accurate chromosome segregation during mitosis, as microtubule detyronisation controls mitotic spindle length and positioning. VASH1 also acts as an angiogenesis inhibitor, suppressing migration, proliferation, and network formation by endothelial cells. This inhibitory effect is specific to endothelial cells, as it does not influence the migration of smooth muscle cells or fibroblasts.

VASH1 is also known as KIAA1036, TTCP 1.

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