VAMP4
Description
The VAMP4 (vesicle associated membrane protein 4) is a protein-coding gene located on chromosome 1.
VAMP4 is a protein encoded by the VAMP4 gene in humans. It belongs to the vesicle-associated membrane protein (VAMP)/synaptobrevin family and is involved in the docking and fusion of synaptic vesicles with the presynaptic membrane alongside synaptobrevins/VAMPs, syntaxins, and SNAP25. VAMP4 might also contribute to trans-Golgi network-to-endosome transport. It has been shown to interact with AP1M1, STX6, and STX16.
VAMP4 plays a role in a pathway that removes an inhibitor (likely synaptotagmin-4) from calcium-triggered exocytosis during the maturation of secretory granules. This suggests VAMP4 may be a marker for this sorting pathway, crucial for reshaping the secretory response of granules.
VAMP4 is also known as VAMP-4, VAMP24.
Associated Diseases
- Parkinson disease
- glaucoma
- Matthew-Wood syndrome
- Meacham syndrome
- immunodeficiency 75
- hepatorenocardiac degenerative fibrosis
- renal-hepatic-pancreatic dysplasia 1
- immunodeficiency 76
- Senior-Boichis syndrome
- autoinflammatory syndrome with immunodeficiency
- granulomatous disease, chronic, autosomal recessive, 5
