UTP15
Description
The UTP15 (UTP15 small subunit processome component) is a protein-coding gene located on chromosome 5.
The UTP15 gene encodes a protein called U3 small nucleolar RNA-associated protein 15 homolog. This protein is involved in the formation of ribosomes, which are essential for protein synthesis.
UTP15 is a ribosome biogenesis factor involved in the nucleolar processing of pre-18S ribosomal RNA. It is essential for optimal transcription of pre-ribosomal RNA by RNA polymerase I. UTP15 is a component of the small subunit (SSU) processome, the initial precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, UTP15 interacts with other ribosome biogenesis factors, an RNA chaperone, and ribosomal proteins. These components work together to achieve RNA folding, modifications, rearrangements, and cleavage, as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
UTP15 is also known as NET21.
Associated Diseases
- multiple sclerosis
- Parkinson disease
- Alzheimer disease
- lysosomal storage disease
- endometrial cancer
- vein disorder
