UTF1
Description
The UTF1 (undifferentiated embryonic cell transcription factor 1) is a protein-coding gene located on chromosome 10.
UTF1, or Undifferentiated Embryonic Cell Transcription Factor 1, is a protein encoded by the UTF1 gene. It is primarily expressed in pluripotent cells such as embryonic stem cells and embryonic carcinoma cells. UTF1 expression declines rapidly during differentiation. It localizes to the nucleus where it plays a role in maintaining the pluripotent chromatin state and regulating mRNA levels by promoting its degradation. Interestingly, UTF1 expression is also found to be aberrantly high in cervical cancer cells, where its promoter loses methylation and becomes abnormally activated. In the male reproductive system, UTF1 expression is limited to specific stages of spermatogonial development, specifically in early type A spermatogonia in rats and the earliest stages of spermatogonium in humans.
UTF1 acts as a transcriptional coactivator of ATF2.
UTF1 is also known as -.
Associated Diseases
- breast cancer
- cancer
- central nervous system germ cell tumor
- post-transplant lymphoproliferative disease
- germinoma
- central nervous system germinoma
- teratoma
