USP33

Description

The USP33 (ubiquitin specific peptidase 33) is a protein-coding gene located on chromosome 1.

Ubiquitin carboxyl-terminal hydrolase 33 is an enzyme that in humans is encoded by the USP33 gene.

== Interactions == USP33 has been shown to interact with DIO2, SELENBP1 and Von Hippel–Lindau tumor suppressor.

USP33, also known as Deubiquitinating enzyme 33, Ubiquitin thioesterase 33, Ubiquitin-specific-processing protease 33, or VHL-interacting deubiquitinating enzyme 1, is a deubiquitinating enzyme that participates in various cellular processes including centrosome duplication, cell migration, and beta-2 adrenergic receptor (ADRB2) recycling. It regulates centrosome duplication by deubiquitinating CCP110 during S and G2/M phases, stabilizing CCP110 during centriole duplication and elongation. USP33 interacts with the intracellular domain of ROBO1, influencing cell migration by regulating Slit signaling. It plays a role in commissural axon guidance across the ventral midline of the neural tube in a Slit-dependent manner, potentially by deubiquitinating ROBO1. USP33 acts as a regulator of G-protein coupled receptor (GPCR) signaling by deubiquitinating beta-arrestins (ARRB1 and ARRB2) and ADRB2. It plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, deubiquitinating it, and inhibiting its lysosomal trafficking. Upon dissociation, USP33 likely transfers to the translocated beta-arrestins, deubiquitinating them and promoting their disengagement from ADRB2, suggesting a dynamic exchange between ADRB2 and beta-arrestins. USP33 deubiquitinates DIO2, regulating thyroid hormone regulation. It mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:19363159, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:23486064}

USP33 is also known as VDU1.

Associated Diseases

WES Whole Exome Sequencing