USP19

Description

The USP19 (ubiquitin specific peptidase 19) is a protein-coding gene located on chromosome 3.

USP19 is a protein encoded by the USP19 gene in humans. It is also known as Ubiquitin carboxyl-terminal hydrolase 19, Deubiquitinating enzyme 19, Ubiquitin thioesterase 19, Ubiquitin-specific-processing protease 19, and Zinc finger MYND domain-containing protein 9.

USP19 is a deubiquitinating enzyme that regulates the degradation of various proteins. It prevents the proteasomal degradation of RNF123, which in turn stimulates the ubiquitin-dependent degradation of CDKN1B, playing a role in cell proliferation. USP19 is involved in decreased protein synthesis in atrophying skeletal muscle and modulates the transcription of major myofibrillar proteins. It is also involved in the turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. USP19 regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. It is required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. USP19 plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis, decreasing the levels of ubiquitinated proteins during skeletal muscle formation and acting to repress myogenesis. USP19 exhibits a preference towards 'Lys-63'-linked ubiquitin chains.

USP19 is also known as ZMYND9.

Associated Diseases

WES Whole Exome Sequencing