UQCR11
Description
The UQCR11 (ubiquinol-cytochrome c reductase, complex III subunit XI) is a protein-coding gene located on chromosome 19.
UQCR11 (ubiquinol-cytochrome c reductase, complex III sub-unit XI) is a protein that in humans is encoded by the UQCR11 gene. UQCR11 is the smallest known component of Complex III in the mitochondrial respiratory chain.
The UQCR11 gene, located on the p arm of chromosome 19 in position 13.3, is made up of 3 exons and is 8,329 base pairs in length. The UQCR11 protein weighs 6.6 kDa and is composed of 56 amino acids. This gene encodes the smallest known component of the ubiquinol-cytochrome c reductase complex, which is also known as Complex III and is part of the mitochondrial respiratory chain. In vertebrates, Complex III contains 11 sub-units: 3 respiratory sub-units, 2 core proteins and 6 low-molecular weight proteins. Proteobacterial complexes may contain as few as three sub-units.
The UQCR11 protein may function as a binding factor for the iron-sulfur protein in Complex III, which is ubiquitous in human cells. Complex III catalyzes the chemical reaction
QH2 + 2 ferricytochrome c
⇌
{displaystyle ightleftharpoons }
Q + 2 ferrocytochrome c + 2 H+ Thus, the two substrates of Complex III are dihydroquinone (QH2) and ferri- (Fe3+) cytochrome c, whereas its 3 products are quinone (Q), ferro- (Fe2+) cytochrome c, and H+. This complex belongs to the family of oxidoreductases, specifically those acting on diphenols and related substances as donor with a cytochrome as acceptor.
UQCR11 is part of the ubiquinol-cytochrome c oxidoreductase (Complex III), a multi-subunit complex in the mitochondrial electron transport chain. It plays a role in transferring electrons from ubiquinol to cytochrome c, contributing to the generation of a proton gradient across the mitochondrial membrane, which drives ATP production. The process involves the Q cycle where protons are transported across the membrane, and electrons are passed to cytochrome c.
UQCR11 is also known as 0710008D09Rik, QCR10, UQCR.
