UGT2A2
Description
The UGT2A2 (UDP glucuronosyltransferase family 2 member A2) is a protein-coding gene located on chromosome 4.
UGT2A2, also known as UDP glucuronosyltransferase 2 family, polypeptide A2, is an enzyme encoded by the UGT2A2 gene. This enzyme is found in the olfactory neuroepithelium, which lines the posterior nasal cavity and is responsible for detecting odors. It is believed to play a role in the termination of odorant signals by transforming odorants into less volatile molecules, allowing for rapid olfactory signal cessation. UGT2A2 and UGT2A1 have been linked to the loss of smell symptom associated with COVID-19.
UGT2A2 is a UDP-glucuronosyltransferase enzyme that plays a key role in phase II biotransformation reactions. It conjugates lipophilic substrates with glucuronic acid, increasing their water solubility and facilitating their excretion via urine or bile. This process is essential for eliminating and detoxifying drugs, xenobiotics, and endogenous compounds. UGT2A2 is particularly involved in the glucuronidation of estradiol, a crucial estrogen hormone. Additionally, it contributes to bile acid detoxification by glucuronidating bile acid substrates, which are essential for dietary lipid absorption. UGT2A2 has also been implicated in detoxification of toxic waste compounds in the amniotic fluid before birth and airborne chemicals after birth.
UGT2A2 is also known as UDPGT 2A2.
